Sawai Man Singh Hospital Study Uncovers Critical Antibiotic Resistance
A 2025 study report from Sawai Man Singh Hospital reveals a troubling trend. Bacteria have learned to survive by developing their own defense mechanisms against antibiotic use. The research examined 9,776 patients and discovered high levels of antibiotic resistance across multiple bacterial infections.
Widespread Resistance to Common Antibiotics
The study identified several key bacteria showing significant resistance. These include Escherichia coli, Klebsiella, Pseudomonas, Staphylococcus aureus, Acinetobacter, and Enterococcus. Ciprofloxacin, one of the most frequently used antibiotics, demonstrated particularly high resistance rates.
In 2,590 cases of Klebsiella infection, ciprofloxacin was resistant in 79% of instances. For Pseudomonas bacterial infection across 1,661 cases, it proved ineffective 54% of the time. The antibiotic failed in 74% of 326 Staphylococcus aureus cases. Acinetobacter bacteria species showed 77% resistance in 1,766 cases.
Escherichia coli infection presented the most concerning data. Ciprofloxacin was resistant in 84% of 4,013 cases. Enterococcus bacteria species infection revealed even higher numbers. Among 2,000 cases, 87% demonstrated resistance to ciprofloxacin antibiotics.
Specific Bacterial Threats and Treatment Challenges
Pathogenic Escherichia coli often causes diarrhea, sepsis, and other clinical symptoms. It remains one of the main intestinal pathogens affecting human health. Ampicillin antibiotics were widely used to treat E. coli infection, but resistance has become a major concern.
The SMS hospital study report showed alarming results. In 93% of 4,013 cases of E. coli bacterial infection, ampicillin antibiotics were found resistant. Only 7% of cases showed beneficial effects from this treatment.
Meropenem, another commonly used hospital drug for infections, also witnessed high bacterial resistance. It was found resistant in 55% of Acinetobacter bacterial infections and 57% of Klebsiella bacteria cases.
Pandemic-Era Antibiotic Shows Emerging Resistance
Doxycycline antibiotic drug gained popularity during the Covid-19 pandemic for its irrational use. It is also widely used for treatment of scrub typhus. The SMS study found this antibiotic now shows resistance against certain bacteria.
Researchers discovered doxycycline was resistant in 36% of Enterococcus bacteria species. It showed 44% resistance in Escherichia coli cases and 34% in Klebsiella bacterial infection cases.
Growing Concerns and Institutional Response
Amoxicillin-clavulanate antibiotic resistance represents a growing concern. Extensive antibiotic use drives this resistance. It affects common pathogens, especially E. coli and Klebsiella, making empirical treatment more difficult.
This resistance particularly impacts urinary tract infections and invasive infections. Prior antibiotic exposure serves as a key risk factor for developing resistance.
In response to increasing antimicrobial resistance among patients, authorities are taking action. A state-level committee of the State IMA is being constituted to curb indiscriminate antibiotic use.
Dr. Lokendra Sharma, chairman of the committee, explained their plan. "This committee formed in December 2025 will coordinate with all branches across the state," he said. "We will establish AMR containment committees at district and branch levels."
The committee will organize workshops to educate doctors and relevant staff about antimicrobial resistance. They will send progress reports to the state office every month. The committee will also review activities conducted by branches under its jurisdiction.
This comprehensive approach aims to address one of modern medicine's most pressing challenges. The study highlights the urgent need for responsible antibiotic use and continued research into alternative treatments.
